Dog Coat Colour (S Locus) Parti, Piebald, or Random White Spotting
There is no single basis for white spotted patterns that occur in animals like cats, dogs and horses. In horses random white spotting, or deletion of colour, has been determined to be caused by more than half a dozen known genetic factors. In more than 25 different dog breeds, a mutation found in a gene called Microphthalmia Associated Transcription Factor-(MITF) is associated with a piebald spotting.
In many breeds piebald behaves as a dosage-dependent trait. This means that dogs with a single copy (Sn) of the MITF variant will express a limited white spotting pattern, while dogs that have 2 copies (SS) of the variant will exhibit more white with very little color. In some breeds dogs that are (SS) are completely white while dogs that are (Sn) have what is referred to as mantle.
As with horses and other animals, dog breeds with white spotting patterns can be affected by additional mutations in MITF and or other genes that affect coat color deletion and distribution.
S Locus Testing:
Animal Genetics offers a test for the S-Locus allele to determine if a dog is Parti, Piebald, or Random White. Spotting Dogs can be DNA tested at ANY age.
Testing Is Relevant for the Following Breeds:
|Boxer||White or Flash|
|Bulldog - English||Piebald|
|Bulldog - French||Piebald|
|Cavalier King Charles Spaniel||White|
|Cocker Spaniel - America||Parti|
|Cocker Spaniel - English||Parti|
|French Brittany Spaniel||Parti|
|German Shorthaired Pointer||and White|
|German Longhaired Pointer||and White|
|German Wirehaired Pointer||and White|
|Portuguese water dog||Parti|
Animal Genetics accepts buccal swab, blood, and dewclaw samples for testing. Sample collection kits are available and can be ordered at Canine Test Now.
Animal Genetics offers DNA testing specific for the mutation in MITF known to be associated with piebald/random white spotting. The genetic test verifies the presence of the mutation and presents results as one of the following. Note- white patterns will vary among individuals and from breed to breed.
|S/S||Piebald||The dog carries two copies of the dominant MITF S allele. The dog will have limited coat color and will always pass on the "S" allele to any potential offspring.|
|S/n||Piebald||The dog carries a single copy of the S allele. The dog will have limited random coat color deletion. The dog can pass on either allele to potential offspring.|
|n/ n||negative||No copies of the MITF S allele where detected. The dog will not pass the MITF mutation on to offspring.|