Links

News Item

July 10th 2017
Animal Genetics will begin offering PRA-prcd testing. Please visit PRA-prcd For more information.

News Item

January, 2016
New performance test available for Pigeons. Please see LDHA-1

News Item

December, 2015
New test available for Horses. Please see Hoof Wall Separation Disease (HWSD)

News Item

April 17, 2012
Animal Genetics publishes 3rd paper on Avian Borna Virus in Avian Diseases. Please contact us for a copy.

L-2-HYDROXYGLUTARIC ACIDURIA
(L-2-HGA)

Description:

Hydroxyglutaric Aciduria or L-2-HGA is a recessive disorder that affects the central nervous system of the dog. Clinical signs usually appear between 6 months and one year (although they can appear later). Symptoms of the disease include some or all of the following, epileptic seizures, "wobbly" gait, tremors, muscle stiffness as a result of exercise or excitement.

 

The disorder presents its self in an autosomal recessive mode of inheritance. This means that two copies of the defective gene (one coming from each parent) have to be present for a dog to be affected by the disease. Dogs with only a single copy of the defective gene and one normal copy of the gene are called carriers. Carriers are not symptomatic and will not develope the disease however, can pass the defective gene onto their offspring. When two healthy carriers are mated, on average 25% of the offspring will be affected by the disease, 50% will be carriers and 25% will be clear.

Sample Type:

Animal Genetics accepts buccal swab, blood, and dewclaw samples for testing. Sample collection kits are available and can be ordered at test now.

Test Is Relevant to the Following Breeds:

Staffordshire Bull Terriers

Results:

Animal Genetics UK offers DNA testing for L-2-HGA. The genetic test verifies the presence of the recessive L-2-HGA gene and presents results as one of the following:

HGA/HGA Affected The dog carries two copies of the mutant gene and is homozygous for the L-2-HGA mutation. The dog is affected by the disease.
HGA/n Carrier Both the normal and mutant copies of the gene detected. The dog can pass on either copy of the defective or non-defective gene to its offspring 50% of the time.
n/n Clear Dog tested negative for the L-2-HGA gene mutation, and will not pass on the defective gene to its offspring.