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January, 2016
New performance test available for Pigeons. Please see LDHA-1

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December, 2015
New test available for Horses. Please see Hoof Wall Separation Disease (HWSD)

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October, 2014
New test available for dogs. Please see Collie Eye Anomaly (CEA)

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June 26, 2013
Animal Genetics now offers testing for 3 DNA markers for splash white pattern in certain breeds of horses.

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April 17, 2012
Animal Genetics publishes 3rd paper on Avian Borna Virus in Avian Diseases. Please contact us for a copy.

Musladin-Leuke Syndrome (MLS)

Description:

Musladin-Leuke Syndrome (MLS) is a recessive mutation that causes the skin, joints and connective tissue in Beagles to be stiff and fibrous. Affected dogs will tend to be smaller and can have a flattened skull, slanted eyes, and a tight coat. The feet can be malformed causing an affected dog to walk on top of its toes. Not all affected dogs will show the full range of symptoms and some will only show minor symptoms. There is no cure for MLS, but the condition is usually not fatal. Most affected Beagles can live normal lives with some extra care.

 

It is possible to avoid producing affected dogs by identifying carriers of the mutation. A simple DNA test will show if an asymptomatic dog is a carrier of MLS. This is a recessive mutation, so both parents would need to be carriers to produce an affected puppy. Breeding a dog that is a carrier with one that does not have the mutation (a "clear" dog) will not produce affected dogs but will pass on the mutation to half of the offspring and they will be carriers.

Sample Type:

Animal Genetics accepts Buccal Swab, Blood, Dewclaw. Collection kits are available and can be ordered at test now.

Test Is Relevant to the Following Breeds:

Beagle

Results:

Animal Genetics offers DNA testing for Musladin-Leuke Syndrome (MLS). The genetic test verifies the presence of the mutation and presents results as one of the following:

MLS/MLS Affected The dog carries two copies of the mutant gene and is homozygous for MLS. This dog will be affected and will and will always pass a copy of the mutation to its offspring.
MLS/n Carrier Both the normal and mutant copies of the gene detected. Dog is a carrier for the MLS mutation and can pass on a copy of the defective gene to its offspring 50% of the time.
n/n Clear Dog tested negative for the MLS gene mutation and will not pass on the defective gene to its offspring.