New Coupon

Download winter2018 Coupon
Please see: winter2018

News Item

New Canine Test
Animal Genetics offers new assay for Susceptibility to Intervertebral Disc Disease (IVDD). Please visit (IVDD) for more information.

News Item

New Canine Test
Animal Genetics offers new assay for Dermatomyositis in dogs. Please visit Dermatomyositis - DMS for more information.

News Item

Canine Test
Animal Genetics will begin offering PRA-prcd testing. Please visit PRA-prcd For more information.

News Item

Avian Test
Performance test available for Pigeons. Please see LDHA-1

News Item

Avian Test
Test available for Horses. Please see Hoof Wall Separation Disease (HWSD)

D-Locus (Dilute Coat Colour)


The MLPH gene codes for a protein called melanophilin, which is responsible for transporting and fixing melanin-containing cells. A mutation in this gene leads to improper distribution of these cells, causing a dilute coat colour. This mutation is recessive so two copies of the mutated gene (or "d" allele) are needed to produce the dilute coat colour.

This mutation affects both eumelanin and phaeomelanin pigments, so black, brown and yellow dogs are all affected by the dilution. However, this effect is more pronounced in black dogs. A dilute black (BB or Bb) dog is generally known as blue, though names do vary for different breeds, such as charcoal or grey. A diluted chocolate (bb) dog is often referred to as a lilac and a diluted yellow (ee) is known as a champagne.

Because the mutation responsible for the dilution phenotype is recessive, a dog can be a carrier of the dilution gene and still appear to have a normal coat colour. These dogs can pass on either the full-coloured or dilute allele to any offspring. This means that two dogs that appear full-coloured can have a dilute puppy. This makes DNA testing for the D-Locus an important breeding tool, whether breeding for a dilute coat, or to avoid it.

Chocolate Dilute Basic Colour Description
B/B or B/b D/D Black
B/B or B/b d/d Blue
b/b D/D Liver/Chocolate
b/b d/d Lilac
e/e D/D Yellow
e/e d/d Champagne

D Locus Testing:

Animal Genetics currently offers a test for the D-Locus to determine how many copies of the recessive allele a dog carries.

Dogs can be DNA tested at ANY age.

Sample Type:

Animal Genetics accepts buccal swab, blood, and dewclaw samples for testing. Sample collection kits are available and can be ordered at Canine Test Now.

Testing Is Relevant for the Following Breeds:

All breeds.


Animal Genetics offers DNA testing for dominant D allele. The genetic test verifies the presence of the mutation and presents results as one of the following:

D/D Non-dilute The dog carries two copies of the dominant "D" allele. The dog will express a normal, non-dilute coat colour and will always pass on a copy of the "D" allele to all offspring.
D/d Carrier of dilute Both the dominant and recessive alleles detected. The dog will have a normal, non-dilute coat and is a carrier of the dilute coat colour. The dog can pass either allele on to any offspring.
d/d Dilute The dog has two copies of the recessive "d" allele and will have a dilute coloured coat. He will always pass on a copy of the dilute allele on to any offspring.