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May, 2018
Animal Genetics offers new assay for Glaucoma in Border Collies. Please visit Glaucoma for more information

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May, 2018
New panel for Warmblood Horses. Please visit WFFS

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July 10th 2017
Animal Genetics will begin offering PRA-prcd testing. Please visit PRA-prcd For more information.

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January, 2017
Performance test available for Pigeons. Please see LDHA-1

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December, 2017
Test available for Horses. Please see Hoof Wall Separation Disease (HWSD)

Hair Shedding (MC5R)

Description:

As we know, not all dogs are alike and when it comes to shedding hair that is also very true. In certain dogs the amount of shedding is far greater then in others. In fact, some breeds like poodles shed very little if any at all. Research has identified a particular variant in a gene (MC5R) that can impact the degree of shedding in various breeds. As is the case with many traits, the degree of shedding is not strictly regulated by one gene but rather a combination of genes functioning together. Further research has identified and link between the shedding (SD locus) and Furnishings or Improper Coat (F locus) (RSPO2). Thus, better understanding the dog's furnishings and shedding genotype will help determine the dog's overall degree of shedding or lack thereof.

 

One copy of the SD variant results in low to moderate shedding while two copies of the variant SD/SD results in higher propensity to shed. Dogs that are negative for furnishings n/n also have a higher propensity to shed while dogs that are F/F are considered to be less prone to shedding. Dogs that are both SD/SD for shedding and negative n/n for furnishings are the most prone to shedding while dogs that are n/n for shedding and F/F for furnishings are the least prone to shedding of any genotype. Different combinations of genotypes will result in varying amounts of shedding.

Sample Type:

Animal Genetics accepts buccal swab, blood, and dewclaw samples for testing. Sample collection kits are available and can be ordered at Canine Test Now.

Testing is Relevant For The Following Breeds:

All dog breeds.

Results:

Animal Genetics offers DNA testing for the recessive "SD" allele. The genetic test verifies the presence of the mutation and presents results as one of the following:

SD/SD High The has two copies of the shedding allele. The dog will have a higher propensity towards shedding and will always pass on the allele to any offspring.
SD/N Medium The has one copy of the shedding allele. The dog will have a average propensity towards shedding and will pass on the allele to any offspring 50% of the time.
N/N Low The has no copies of the shedding allele. The dog will have a low propensity towards shedding and will never pass on the allele to any offspring.

Combined Shedding and Furnishings Results:

Table reflects the combination of Shedding and Furnishings allele results

Shedding Allele Furnishings Allele Level of Shedding
N/N F/F Lowest
N/N F/F Low
SD/N N/F Low
N/N N/N Moderate
SD/N N/F Moderate
SD/SD F/F Moderate
SD/N N/N Moderate High
SD/SD N/F Moderate High
SD/SD N/N High