Factor VII Deficiency (FVII)
Factor VII (FVII) Deficiency is a mutation that reduces the amount of Factor VII available for normal blood coagulation in Beagles and several other breeds including Airedale, Alaskan Klee Kai, Giant Schnauzer and Scottish Deerhound.
The condition is not fatal but can cause increased bleeding after surgery or injury in affected dogs. In rare circumstances, an affected dog may experience excessive bleeding and require a blood tranfusion.
The mutation is an autosomal recessive trait, so a dog who is a "carrier" of the mutation (has one copy of defective gene) may or may not pass on the mutation to its offspring.
Carriers are generally asymptomatic, and even "affected" dogs (have two copies of defective gene) may exhibit mild or no symptoms.
It is therefore useful to test for the presence of the mutation before breeding.
Animal Genetics accepts buccal swab, blood, dewclaw. Collection kits are available and can be ordered at test now.
Test Is Relevant to the Following Breeds:
Airedale, Alaskan Klee Kai, Beagle, Giant Schnauzer and Scottish Deerhound
Animal Genetics offers DNA testing for Factor VII (FVII). The genetic test verifies the presence of the recessive mutation and presents results as one of the following:
|FVII/FVII||Affected||The dog carries two copies of the mutant gene and is homozygous for FVII. This dog will be affected and will always pass a copy of the mutated gene to its offspring.|
|FVII/n||Carrier||Both the normal and mutant copies of the gene detected. Dog is a carrier for the FVII mutation and can pass on a copy of the defective gene to its offspring 50% 0f the time.|
|n/n||Clear||Dog tested negative for the FVII gene mutation and will not pass on the defective gene to its offspring.|
Submit a Sample for Testing:
Cost per sample is £45 or €56. Please see our fee schedules below for bulk and combination rates.