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Hereditary Hyperuricosuria (HUU)


Dogs with this genetic mutation metabolize waste product s as uric acid in their urine. The uric acid forms into hard stones in the bladder, causing pain and inflammation as the stone moves through the urinary tract.


A dog that has difficulty urinating or appears to have an inflamed bladder may have HUU. Other signs can include blood in the urine and frequent urination. If the dog is unable to pass the urate stones without medical intervention, surgery may be required to remove them. And if the urinary tract is blocked, the condition can be life threatening. Even in the best case scenario, HUU is uncomfortable and painful for the dog.

The mutation is autosomal recessive. Both parents will need to be carriers of the mutation to pass it on to their offspring. Carriers will not show any symptoms of HUU and even affected dogs may not show any signs, so it is important to test dogs for HUU prior to breeding.

Sample Type:

Animal Genetics accepts Buccal Swab, Blood, Dewclaw. Collection kits are available and can be ordered at test now.

Test Is Relevant to the Following Breeds:

All Breeds including, American Bulldog, Bulldog, French Bull Dog, American Pitbull Terrier, American Staffordshire Terrier, Australian Shepherd, Black Russian Terrier, Bulldog, Catahoula Leopard Dog, Dalmatian, German Shepherd, Giant Schnauzer, Jack Russel/Parsons Terrier, Labrador Retriever, Large Munsterlander, South African Boerboel, Vizsla and Weimaraner, Hungarian Vizsla.


Animal Genetics offers DNA testing for Hereditary Hyperuricosuria. The genetic test verifies the presence of the recessive gene and presents results as one of the following:

HUU/HUU Affected The dog carries two copies of the mutant gene and is homozygous for HUU. This dog will be affected and will always pass on the defective gene to it's offspring.
HUU/n Carrier Both the normal and mutant copies of the gene detected. Dog is a carrier for HUU and can pass on a copy of the defective gene to its offspring 50% of the time.
n/nClear Dog tested negative for the mutant gene and will not pass on the defective gene to its offspring.