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New Canine Test
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Musladin-Leuke Syndrome (MLS)


Musladin-Leuke Syndrome (MLS) is a recessive mutation that causes the skin, joints and connective tissue in Beagles to be stiff and fibrous. Affected dogs will tend to be smaller and can have a flattened skull, slanted eyes, and a tight coat. The feet can be malformed causing an affected dog to walk on top of its toes. Not all affected dogs will show the full range of symptoms and some will only show minor symptoms. There is no cure for MLS, but the condition is usually not fatal. Most affected Beagles can live normal lives with some extra care.


It is possible to avoid producing affected dogs by identifying carriers of the mutation. A simple DNA test will show if an asymptomatic dog is a carrier of MLS. This is a recessive mutation, so both parents would need to be carriers to produce an affected puppy. Breeding a dog that is a carrier with one that does not have the mutation (a "clear" dog) will not produce affected dogs but will pass on the mutation to half of the offspring and they will be carriers.

Sample Type:

Animal Genetics accepts Buccal Swab, Blood, Dewclaw. Collection kits are available and can be ordered at test now.

Test Is Relevant to the Following Breeds:



Animal Genetics offers DNA testing for Musladin-Leuke Syndrome (MLS). The genetic test verifies the presence of the mutation and presents results as one of the following:

MLS/MLS Affected The dog carries two copies of the mutant gene and is homozygous for MLS. This dog will be affected and will and will always pass a copy of the mutation to its offspring.
MLS/n Carrier Both the normal and mutant copies of the gene detected. Dog is a carrier for the MLS mutation and can pass on a copy of the defective gene to its offspring 50% of the time.
n/n Clear Dog tested negative for the MLS gene mutation and will not pass on the defective gene to its offspring.