Neonatal Encephalopathy with Seizures (NEwS)
Neonatal encephalopathy with seizures (NEWS) is an autosomal recessive disease of standard poodle puppies. Affected puppies are small and weak at birth. Many die in their first week of life. Those surviving past 1 week develop ataxia, a whole-body tremor and by 4 to 6 weeks of age, severe generalized clonic-tonic seizures. None have survived to 7 weeks of age. Cerebella from affected puppies were reduced in size.
This fatal disease affects the brain of newborn puppies causing weakness and seizures and ultimately death within a few weeks of birth. Neonatal encephalopathy is recessive — both parents must possess the gene mutation in order to produce offspring affected by the disease. Dogs with one copy of this gene do not show symptom, but are carriers and can pass the gene to their offspring.
Animal Genetics accepts buccal swab, blood, and dewclaw samples for testing. Sample collection kits are available and can be ordered at test now.
Test Is Relevant to the Following Breeds:
- Standard Poodle
Animal Genetics UK offers DNA testing for Neonatal encephalopathy with seizures (NEWS). The genetic test verifies the presence of the recessive mutation and presents results as one of the following:
|NE/NE||Affected||The dog carries two copies of the mutant gene and is homozygous for the MDR1 mutation. The dog will react to Ivermectin, or other listed drugs and will always pass on a copy of the mutated gene to its offspring.|
|NE/n||Carrier||Both the normal and mutant copies of the gene detected. Some sensitivity to listed drugs can occur. Dog is a carrier for the MDR1 mutation and can pass on a copy of the defective gene to its offspring 50% 0f the time.|
|n/n||Clear||Dog tested negative for the MDR gene mutation and will not pass on the defective gene to its offspring.|