News Item

Canine Test
New test available for Cocoa (French bulldog chocolate)
Please see: Cocoa

News Item

Equine Test
Test available for Horses. Please see Immune Mediated Myositis (IMM)

News Item

New Canine Test
Animal Genetics offers new assay for Neuronal Ceroid Lipofuscinosis (NCL) in Golden Retrievers. Please visit NCLGR for more information.

News Item

New Canine Test
Animal Genetics offers new assay for Susceptibility to Intervertebral Disc Disease (IVDD). Please visit IVDD for more information.

News Item

New Canine Test
Animal Genetics offers new assay for Dermatomyositis in dogs. Please visit Dermatomyositis - DMS for more information.

News Item

Canine Test
Animal Genetics will begin offering PRA-prcd testing. Please visit PRA-prcd For more information.

News Item

Avian Test
Performance test available for Pigeons. Please see LDHA-1

News Item

Equine Test
Test available for Horses. Please see Hoof Wall Separation Disease (HWSD)

von Willebrand's Disease Type I


Von Willebrand disease (vWD) is an inherited bleeding disorder that inhibits the normal blood clotting process, causing prolonged bleeding after an injury. People with this condition often experience excessive bruising, prolonged nosebleeds, and excessive bleeding following any form of trauma, including surgery, or dental work.

The primary function of von Willebrand factor (vWF) a blood glycoprotein, is to bind itself to other proteins. The deficiency or failure of vWF function inhibits the blood coagulation process and causes bleeding which is most apparent in tissues having high blood flow or narrow vessels.

Von Willebrand's disease type I (vWDI):

In dogs (as well as in people), three separate types of vWD have been identified. Of these three types there are five different genetic mutations causing vWDs in dogs. Genetic tests have been developed to identify all five variants. Von Willebrand's disease type I (VWDI) is transmitted as an autosomal recessive trait with variable penetrance and is the least serious of the three.

The causal mutation for VWDI is a G>A substitution. The mutation reduces the normal production of von Willebrand's factor (vWf) in affected dogs to only 5-10% of normal vWf production. This low concentration of normal vWf prevents normal blood coagulation resulting in excessive bleeding.

Symptoms include: Abnormal Bleeding, Abnormal Blood Clotting, Bleeding Gums, Blood In The Feces, Blood In The Urine, Easy Bruising, Excessive Bleeding, Hematochezia, Hematoma, Hematuria, Nosebleeds, Vaginal Bleeding.

Sample Type:

Animal Genetics accepts buccal swab, blood, and dewclaw samples for testing. Sample collection kits are available and can be ordered at Canine Test Now.

Test Is Relevant to the Following Breeds:

Animal Genetics is currently only offering testing for von Willebrand's disease type 1. This mutation has been detected in the following breeds:

  • Australian Labradoodle
  • Bernese Mountain Dog
  • Cardigan Welsh Corgi
  • Coton de Tulear
  • Doberman Pinscher
  • Drentsche Patrijshond
  • Dutch Partridge Dog
  • German Pinscher
  • Goldendoodle
  • Irish Red and White Setter
  • Irish Setter
  • Kerry Blue Terrier
  • Labradoodle
  • Manchester Terrier
  • Miniature Poodle
  • Papillon
  • Pembroke Welsh Corgi
  • Poodle
  • Stabyhoun
  • Standard and Toy Poodle
  • West Highland White Terrier


Animal Genetics UK offers DNA testing for Canine vWD Type 1. The genetic test verifies the presence of the recessive mutation and presents results as one of the following:

vWD1/vWD1 Affected The dog carries two copies of the mutant gene and is homozygous for vWD Type 1. This dog will be affected and will always pass on a copy of the mutated gene to its offspring.
vWD1/n Carrier Both the normal and mutant copies of the gene detected. Dog is a carrier for the vWD Type 1 mutation and can pass on a copy of the defective gene to its offspring 50% of the time.
n/n Clear Dog tested negative for the gene mutation that causes vWD Type 1 and will not pass on the defective gene to its offspring.